Psychedelic Information Theory
Shamanism in the Age of Reason
Search Results : inhibition
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... is shown to be upstream of DNA synthesis as inhibition of signaling components such as pertussis toxin-sensitive G proteins, L-type Ca2+ channels, phospho-lipase C, intracellular Ca2+ release, protein kinase C, and mitogen-activated protein or ...
... but it was blocked upon phospholipase C inhibition. These results suggest a novel mechanism wherein, upon DAMGO binding, CaM is released from the μ receptor and activates phospholipase C. Subsequently, phospholipase C generates diacylg...
Role of GABAB receptor-mediated inhibition in reciprocal interareal pathways of rat visual cortex
In neocortex, synaptic inhibition is mediated by gamma-aminobutyric acid-A (GABAA) and GABAB receptors. By using intracellular and patch-clamp recordings in slices of rat visual cortex we studied the balance of excitation and inhibition in different ...
A systems model of altered consciousness: integrating natural and drug-induced psychoses
... of homologues gating functions, such as prepulse inhibition of the startle reflex, in animal and human models of psychosis corroborate this view and provide a translational testing mechanism for the exploration of novel pathophysiologic and therapeu...
5-HT2A Agonism and Multisensory Binding
... receptor agonists (hallucinogens) promote disinhibition and excitability in 5-HT mediated pathways, indicating that psychedelic action is the product of spontaneous nonlinear feedback excitation in the recurrent circuits responsible for real-tim...
... a previously unknown and extremely potent inhibition of tumor necrosis factor (TNF)-α-mediated inflammation. 5-HT2A receptor stimulation with the agonist (R)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane [(R)-DOI] rapidly inhibits a var...
... are caused by a loss of lateral or localized inhibition within cortical circuits.3 The level of disinhibition and drift in the visual field is proportional to the dose of hallucinogen, and this assumption is proved correct by individual reports ...
Presynaptic uptake blockade hypothesis for LSD action at the lateral inhibitory synapse in Limulus
... responses from eccentric cells while producing inhibition either by light or by antidromic stimulation of the optic nerve in the presence of LSD, serotonin (5-HT), chlorimipramine, or a bathing medium whose high Mg++ and low Ca++ concentrations pa...
DOI disrupts prepulse inhibition of startle in rats via 5-HT2A receptors in the ventral pallidum.
... receptors are known to be involved in prepulse inhibition of the startle response (PPI), a measure of sensorimotor inhibition that is deficient in schizophrenia, Huntington's disease, and obsessive compulsive disorder. In the present studies, the ...
EEG coherence in post-LSD visual hallucinations
... data that, in HPPD, there is widespread cortical inhibition in the eyes-opened state, but localized and isolated occipital disinhibition upon eye closure, a state known to facilitate hallucinatory experiences. An analogy is drawn to findings in the ...
Bypassing interneurons: inhibition in neocortex
... interneuron, allowing the rapid and powerful inhibition of another pyramidal cell....
Scientists explain inception of perception in the brain
... speed of their response is what causes this fast inhibition," Cruikshank said. "What’s exciting about these findings is that they help to explain how the cortex handles information at the very earliest stages of processing. And understanding t...
... specific to each sublamina. Regions with less inhibition have higher spontaneous activity, larger CRFs and broader orientation tuning. Where inhibition is stronger, spontaneous activity almost disappears, CRFs shrink, and orientation selectivity ...
Local cortical lesions abolish lateral inhibition at direction selective cells in cat visual cortex
... of an optimally oriented stimulus. Postsynaptic inhibition has been suggested to generate this direction selectivity in simple cells, but the intracortical pathways involved have not been identified. While continuously recording from simple cells i...
Orientation selectivity in visual cortex by fluctuation-controlled criticality
... we showed that, using a strong network inhibition countered by feedforward and recurrent excitation, the cortical model reproduced many observed properties of simple and complex cells. However, that network’s complex cells were po...
The Control Interrupt Model of Psychedelic Action
... continuity. Constraint, Control, and Feedback inhibition Feedback excitation is applied in sensory circuits to amplify salient input, but the majority of the brain’s feedback circuits are inhibitory, meaning that human consciousness is more co...
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