Psychedelic Information Theory
Shamanism in the Age of Reason
Search Results : dendrites
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... postsynaptic currents (EPSCs) in apical dendrites of layer V pyramidal cells of prefrontal cortex; this effect was mediated by 5-HT2A receptors, a proposed site of action of hallucinogenic and atypical antipsychotic drugs. Unexpectedly, alt...
... concentrations of this receptor on the apical dendrites of pyramidal cells in layer V of the cortex may modulate cognitive processes,[5][6][7] by enhancing glutamate release followed by a complex range of interactions with the 5-HT1A,[8] GABAA,[9...
... excitatory postsynaptic potentials at apical dendrites of layer V cortical pyramidal cells. We propose that an effect of hallucinogens upon glutamatergic transmission in the cerebral cortex may be responsible for the higher-level cognitive, perc...
5-HT2A Agonism and Multisensory Binding
... density of 5-HT2A receptors are expressed on the dendrites of cortical layer V pyramidal cells3,4,5,6,8, and the highest density of layer V dendrites project upward into the arbors of cortical layer I, the very outward surface of the brain. 5-HT2A r...
By intracellular and whole cell recording in rat brain slices, it was found that bath-applied serotonin (5-HT) produces an increase in the frequency and amplitude of spontaneous excitatory postsynaptic potentials/currents (EPSPs/EPSCs) in layer V pyr...
... a flood of glutamate wherever shafts of apical dendrites intersect with lateral projections from proximal neural columns.18 Glutamate flooding at lateral dendritic arbors of pyramidal neurons is the result of asynchronous glutamate release in the ...
... of the supraoptic nucleus, have only one or two dendrites, each of which receives thousands of synapses. Synapses can be excitatory or inhibitory and will either increase or decrease activity in the target neuron. Some neurons also communicate via ...
... to their parallelly aligned proximal apical dendrites that formed two intensely stained bands above and below layer IV. In double-label experiments, 5-HT2A label was found in calbindin D28k-positive, nonphosphorylated-neurofilament-positive, an...
Cortical Region Interactions and the Functional Role of Apical Dendrites
The basal and distal apical dendrites ofpyramidal cells occupy distinct cortical layers and are targeted by axons originating in different cortical regions. Hence, apical and basal dendrites receive information from distinct sources. Physiological ev...
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